It started around 2 p.m. near S Avalon and E Alondra boulevards. An employee told ABC7 a barrel of hand sanitizer exploded and believes it prompted the fire.
The official cause of the fire has not been released.
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Video from above the fire at its peak showed the flames being fueled by hundreds of burning pallets.
Fire officials confirmed to Eyewitness News that some of those pallets were packed with a variety of items, including products made with rubbing alcohol. They say the distribution center consists of several floors, all stocked with different items.
No injuries were reported.
The employee said once he saw flames, he immediately started telling others to get out.
"We were out back, unloading trailers, and we heard one big explosion," he said. "It was a barrel exploding. We then looked back and saw a whole bunch of flames."
According to a tweet posted by the Los Angeles County Fire Department, there were a total of about 200 firefighters working to put the fire out.
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Los Angeles County Supervisor Holly Mitchell also took to Twitter, alerting residents in the area to stay indoors.
"While no evacuations are needed, residents are recommended to stay indoors and close their windows due to the heavy smoke in the air. Please stay safe!" she wrote.