The stubborn blaze began about 5 a.m. at a single-store structure in the 1300 block of Margo Street, where crews initially attacked the flames from atop the structure. About thirty minutes later, firefighters abandoned the rooftop and went into a defensive mode, dousing the fire with water cannons mounted on aerial ladders.
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The business was "filled with densely stored clothing," the LAFD said in a statement.
There were no reports of injuries, and the fire was prevented from spreading to adjacent buildings.
The blaze was fully extinguished about 8:30 a.m., the Fire Department said.
The cause of the fire was not immediately known.
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The Los Angeles Police Department urged motorists to avoid the intersection of Pico Boulevard and Olive Street, which was closed with more than a dozen fire engines at the scene.