Los Angeles City firefighters were able to put out the flames and contain the blaze to the restaurant located on the ground floor of the building in the 200 block of S. Grand Avenue. One person was taken to the hospital with burn injuries, according to LAFD.
The fire broke out shortly before 8:30 a.m. The smoke from the blaze traveled through different parts of the 27-floor building, LAFD said.
The fire department says that the building engineer and LAFD Fire Prevention Bureau inspector are on scene to operate the building's smoke removal system to clear the remaining smoke out of the building.
Firefighters were able to recall, and clear out all elevators, but it was not immediately known how many people were in those elevators.
Crews also located people on the 16th and 19th floors but they did not need medical aid, officials said. Several workers who were on the roof of the building at the time were escorted out safely by fire crews.
Firefighters looked into additional calls that were coming from people in different parts of the building, and provided assistance, according to the fire department.
Building occupants remain sheltered-in-place.
LAFD says they are looking into unconfirmed reports that a possible explosion may have occurred in the kitchen of the restaurant.
It's still an active scene in the busy downtown area, and traffic will be impacted as fire crews and LAFD arson investigators work to determine the cause of the fire.