The blaze was reported shortly after 3 a.m. at an 80,000-square-foot building in the 8000 block of North Vineland Avenue, according to the Los Angeles Fire Department.
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No injuries were immediately reported, and it was unclear if anyone was inside the single-story structure when the fire began.
Firefighters initially took up defensive positions at the scene, as massive flames and smoke emanated from the building's roof, which later collapsed.
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The LAFD declared the incident to be a "major emergency," and arson investigators were summoned to the location in accordance with protocol, a news release said.
At about 4:45 a.m., the Fire Department announced that the fire was extinguished.