The blaze erupted about 12:40 p.m. in the 200 block of South Earlham Street, according to the Orange Fire Department. Firefighters arrived to find downed power lines at the scene.
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Three firefighters suffered electric shocks while battling the flames and were transported to a medical center, officials said.
A civilian was also hurt inside the home and was hospitalized. The nature of that person's injuries was unknown.
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The cause of the incident is under investigation.