A Toyota Camry collided with the big rig in the incident, which was reported shortly before 4:30 a.m. near Magnolia Avenue, according to the California Highway Patrol.
The driver of the sedan was uninjured, the CHP said. The Metro Cities Fire Authority said one person was transported to a hospital.
All eastbound lanes were closed in the immediate aftermath of the collision. The Highway Patrol later opened three lanes as a heavy-duty tow truck crew began clearing the wrecked semi-truck from the scene.