The shooting was reported in the 200 block of East 119th Street just before 6 p.m. Los Angeles Fire Department officials said they were treating five patients at the scene.
Police say they believe there were two vehicles involved in a drive-by shooting that was gang related and more than a dozen rounds were fired.
Five people were transported to local hospitals.
Additionally, a fire department vehicle responding to the shooting with its lights and siren on collided with a civilian vehicle at Main Street and Florence Avenue, officials said.
Three civilians sustained non-life-threatening injuries, including one male driver and two female pedestrians, according to the Los Angeles Fire Department. LAPD is investigating the collision.
DEVELOPING: This story will be updated.