The shooting occurred near E. Palmer Avenue and Boynton Street at approximately 9:15 p.m. A neighbor reported hearing gunshots.
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Glendale police encountered a man with a gunshot wound when they responded to the shooting.
Police said the suspect, a man in his 50s, ran from the scene.
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The identity of the victim was not immediately released, but police said he is recognized as someone who lives in the neighborhood.
"Two men were visiting family and they were leaving. They were approached from behind, and one of them was shot and the other one is not injured," said Sgt. Dan Suttles of the Glendale Police Department.
Police said at this point in the investigation, they do not believe the victim and the suspect knew each other.
Several streets in the area were blocked off during the investigation.