Crews responded about 11:35 p.m. Thursday to the 200 block of Rimpau Boulevard, near Third Street, according to Nicholas Prange of the Los Angeles Fire Department.
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A knockdown was declared about 12:10 a.m. Friday, Prange said.
Witnesses says the vehicle was traveling at an estimated 90 mph when the driver lost control, hit a curb and went airborne before slamming into a tree near a bedroom of the home.
"A little girl was in a bedroom and stepped out of that room, otherwise this could have been a real tragedy,'' LAPD Capt. Brian Wendling told reporters at the scene.
The driver of the vehicle was pronounced dead at the scene.
A skid mark in excess of 300 feet was visible on Third Street in the area of the crash, Wendling said.
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The name of the driver was not immediately released.
Officials say the home was yellow-tagged, with the family able to enter the house but not the garage.
City News Service contributed to this report.