It happened Thursday evening near a Food For Less grocery store at the intersection of Parthenia Street and Woodley Avenue.
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Police said the driver of a 1992 white BMW was heading southbound on Woodley Avenue at a high rate of speed when it slammed into the motorcyclist who was exiting a nearby parking lot.
"The collision caused the motorcyclist to continue in a southwest direction colliding with a parked vehicle," said police in a statement.
The motorcyclist, who was identified only as a man in his 50s, died at the scene. Police said the driver of the BMW kept going and ended up crashing into a parked vehicle.
The driver got out of the car and fled on foot, leaving a passenger behind, according to investigators. The driver remains at large. Police did not release further details on the passenger.
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The BMW has since been recovered and is now in police custody.
Anyone with information is urged to contact Valley Traffic Division Officer Garcia at 818-644-8117 or Detective Ortega at 818-644-8035. Anyone wishing to remain anonymous can contact Crime Stoppers at 1-800- 222-TIPS (800-222-8477) or visit the Crime Stoppers website.