The shooting was reported about 6:30 a.m.at Sunset Boulevard and Orange Drive, according to the Los Angeles Police Department.
The suspect, an unidentified woman, allegedly walked up to the vehicle and opened fire.
The victim was taken to a hospital where he died. Information on his identity was not immediately available.
A motive was not immediately known.
Anyone with information on the case is urged to call 877-LAPD-247.
City News Service contributed to this report.