The fire was reported at 6:26 p.m. in the 1300 block of North Custer Avenue.
Firefighters arrived to find a home fully involved in flames and three people trapped inside.
"There were three people trapped inside the home. Two of them got out safely and the third, a woman, was carried out by firefighters," Orange County Fire Authority Capt. Stephen Horner said
She had minor injuries and was taken to a hospital for treatment. No other serious injuries were reported.
The fire caused major damage to the home and was extinguished after 18 minutes.
The cause of the fire is under investigation.
City News Service contributed to this report.