The crash happened in the 2400 block of E. Florence Avenue, according to the Los Angeles County Fire Department.
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Officials said those hospitalized were two juveniles and one adult. One victim was struck by the vehicle and transported to a trauma center in critical condition, fire officials said. One other victim is in critical condition and the driver of the car was transported with minor injuries.
Two other patients were treated at the scene, fire officials said. None of the injuries are life-threatening, officials said.
A silver sedan was spotted fully inside the restaurant as emergency response crews surrounded the scene. It appeared the car jumped the curb off of Santa Fe Avenue, into the drive-thru window and the main dining room of the business.
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One Carl's Jr. employee said the crash sounded like an earthquake.
"I heard like a loud crash and I saw the dust up in the air, and I was like, 'Oh, maybe it's an earthquake or something' and as I come out, the car was inside, the lady was screaming and I was in shock, and once I got close, ...I saw a kid. He was under, like, the bumper," the employee said.
The cause of the crash was not immediately known. Police said speed was a factor.