Los Angeles County Fire Department paramedics responded to the area of Randolph Place and Maywood Avenue around 8:45 p.m. following a report of a collision.
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Several ambulances were called to the scene, along with Huntington Park police.
Footage from the scene showed one vehicle with front-end damage, and another damaged car next to a fallen light pole.
Two people were pronounced dead at the scene.
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Two others were rushed to a hospital in critical condition, authorities said. Another person suffered minor injuries.
It's unclear what led up the crash.