It's the chain's first-ever permanent closure.
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RELATED: Community sad with In-N-Out's decision to close Oakland location due to crime
Crime on the property and along the Hegenberger corridor is the reason behind it.
Other businesses in the area, including a Subway and a Denny's, have also closed over safety concerns.
RELATED: In-N-Out in Oakland to close over increase in crime, company says
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The Oakland restaurant is No. 193 and opened in 2005, according to In-N-Out's list.
In-N-Out didn't say what, if anything, would happen to Oakland's store number.