The chase started just before 11 a.m. after the bull escaped from a nearby slaughterhouse. Officials quickly cornered it in a backyard on Marsden Street in Jamaica.
While officers were clearing the block in the event the bull escaped again, they managed to sedate the bull using darts. But the determined bull broke free again.
Watch video of the bull chasing after people here:
Video shows bull chasing after people in Queens
It went on a run through the neighborhood, with police not far behind trying to corner it.
More than an hour later, police cornered the bull again and sedated it. It was in the process of being taken to a local animal shelter, but didn't survive for long.
Watch video of police chasing the bull through the city:
Live coverage of bull on the run in Queens
Animal Care Centers said the bull arrived at their Brooklyn facility dead on arrival.
The animal was given two different drugs during the attempted capture:
1. Darts - a tranquilizer called Ketaset, which was administered by ESU
2.Poll syringe - 1cc of Xylazine, which was administered by the NYPD mounting division
The bull escaped from a slaughterhouse, officials said, and police were trying to get workers to come to the scene to capture it.