Firefighters responded to the two-vehicle collision around 3:40 a.m., near Arlington Avenue and Exposition Boulevard, and found three people trapped in the wreckage, according to Margaret Stewart of the Los Angeles Fire Department.
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Two of the victims were pronounced dead at the scene and a third was freed from the wreckage and taken to a hospital in critical condition, Stewart said.
The identities of the victims have not been released and the cause of the crash is under investigation.
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City News Service contributed to this report.