The hazmat emergency was reported about 10:15 a.m. in the 2200 block of Via Cerro, just east of Market Street, according to the Riverside County Fire Department.
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A half-dozen engine crews and several ambulances were sent to the location, where initially three people reported feeling ill, fire officials said.
The entire building was evacuated.
At 12:46 p.m., the Fire Department said a hazardous materials team was making entry into the building.
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The two firefighters were treated and released from the hospital, the agency said on Twitter. There was no immediate update on the civilians' conditions.