The shooting occurred about 7 p.m. near the intersection of Vermont Avenue and Sixth Street, a spokesperson for the Los Angeles Police Department said.
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The victim was pronounced dead at the scene, the spokesperson said. His identity was withheld, pending notification of his family.
No witnesses were found, according to police, and a description of the at-large shooter was not available.
The circumstances that led to the shooting were unknown.
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Anyone with information about the incident is urged to call LAPD West Bureau homicide detectives at 213-382-9470 or 213-972-2971.