The driver of a Ford Expedition ended up in the front yard of a home in Lake Balboa after hitting five other cars, two motorcycles and some power poles.
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It happened on Vanowen Street and Yarmouth Avenue just after 11 p.m. Thursday.
One of the vehicles hit in the crash ended up crashing into a nearby business.
The driver who ended up in the front yard was taken to the hospital in critical condition.
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Three other people were treated at the scene. The crash caused damage and flooding in the area.
The cause of the collision remains unknown.