Surveillance video obtained by Eyewitness News shows the moment the SUV turned into the path of a motorcycle traveling at high speeds.
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The impact of the crash sent two people on the motorcycle flying down the street.
The crash happened in the 7000 block of Woodley Avenue around 7:15 p.m., according to Los Angeles police.
Witnesses heard the crash and rushed to help, but says there was little they could do.
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"There were two people on the ground," Eder Macal said. "We were just shocked, and we were shaking. It's just really sad."
Witnesses also said a fire station is just a few blocks away and first responders were on the scene in just minutes.
Paramedics transported both people thrown from the motorcycle, but witnesses said neither were visibly responding to life-saving measures. LAPD confirmed one of them died.