The crash happened at about 3 p.m. at the intersection of Avenue K and Sierra Highway, according to sheriff's officials.
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The deputy was going southbound on Sierra Highway and through the intersection when he was struck on the side by a driver going eastbound.
RAW VIDEO: Lancaster patrol car struck, causing chain-reaction crash
The patrol car then collided with two other vehicles. A total of four cars were involved in the wreck.
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The driver of the patrol vehicle was transported to a hospital with minor injuries. No one else was hospitalized, officials said.
No arrests were immediately made.