The incident happened around 9 p.m. Wednesday on Sierra Highway, according to the Los Angeles County Sheriff's Department.
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When deputies arrived, they found one man inside a motel room suffering from an apparent gunshot wound. He was pronounced dead at the scene.
Another man was found with a gunshot wound in the parking lot. He later died at the hospital.
Neither of the victims have been identified.
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Investigators believe there were multiple suspects involved, but additional details about the robbery were not available.
Anyone with information is encouraged to contact homicide detectives at (323) 890-5500.