The crash was reported just before 6 p.m. Monday on Challenger Way at Avenue E.
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It's unclear what led up to the crash but video from the scene shows a Kia Sorento off to the side of the road and the big rig with visible damage to its front right end.
The California Highway Patrol said the sedan was in the middle of the roadway at the time of the crash but did not elaborate as to how or why the vehicle was there.
Investigators said the driver of the sedan, who has not been identified, died at the hospital.
Two minors who were also in the sedan were also sent to the hospital but their conditions are unknown.
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It's unclear if the driver of the big rig was injured.
The cause of the crash remains under investigation.