The fire was reported at 10:05 p.m. Sunday in the 45500 block of 11th Street West, according to Los Angeles County Fire Department Dispatch Supervisor Martin Rangel.
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The single-story house was well-involved in flames when firefighters arrived, Rangel said.
Firefighters had the flames out at 10:22 p.m., he said.
A battalion chief at the scene confirmed the dogs' deaths and said the American Red Cross was contacted to aid the displaced residents.
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The cause of the fire was under investigation by the sheriff's department, he said.