The incident was reported shortly after midnight in the 45500 block of Barrymoore Avenue, where the woman was pronounced dead at the scene, according to the Los Angeles County Sheriff's Department.
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The victim was described as about 50 to 55 years old. Her name was not immediately released.
"A male who was discovered in the house has been currently detained," the sheriff's department said in a statement. "There is no additional information available at this time."
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The sheriff's Homicide Bureau urged anyone with information regarding the death to call (323) 890-5500 or Crime Stoppers at (800) 222-8477.