In a statement, the Los Angeles Police Department said Moore drove himself to Los Angeles County + USC Medical Center on Monday because he "was not feeling well."
The chief was admitted for testing and observation but the department says he "is in great spirits and appreciates your well-wishes and support."
The department announced Tuesday evening Moore was released from the hospital.
"My thanks & appreciation to the outstanding medical staff at USCMC. Truly dedicated and caring professionals," Moore tweeted after his release, adding that he is back at home.
No other details about his condition were released.