Paramedics sent to Century Boulevard and Hoover Street about 8:55 p.m. Thursday pronounced the man dead at the scene, the Los Angeles Police Department reported.
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Police say they believe the man, whose name was not immediately available, was on the roadway when hit by a vehicle that was eastbound on Century Boulevard.
"There is no suspect information at this time and the vehicle is described as a dark-colored pickup truck," police said in a statement.
A standing reward of up to $50,000 has been offered by the city of Los Angeles for help solving a fatal hit-and-run.
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Anyone with information on the case was urged to call the LAPD South Traffic Division at 323-421-2500, or 877-LAPD-24-7. Tipsters may also call Crime Stoppers at 800-222-TIPS, or use the website www.lacrimestoppers.org.