Officers had responded to reports of a man with a gun, a Los Angeles Police Department spokesperson said.
The suspect was transported to a hospital where he was pronounced dead. No officers were injured.
It was unknown if the suspect was armed at the time of the shooting.
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According to the LAPD, the shooting occurred shortly before 1 p.m. at a Shell gas station at the corner of Sepulveda Boulevard and Tuller Avenue.
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The incident prompted a massive police presence and the closure of multiple streets at the scene. Heavy delays were expected for up to 14 hours as the investigation continued.