No injuries were reported in the incident, which occurred shortly after noon on the southbound side of the freeway, a spokesperson for the Los Angeles Police Department said. The officers did not return fire, the spokesperson said.
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A suspect was taken into custody but was not immediately identified.
About 1:45 p.m., the California Highway Patrol closed all of the 110's southbound lanes so that investigators could scour the scene for evidence. Southbound traffic was diverted onto the 10 Freeway.
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Less than an hour later, all lanes were reopened.