The Lexi Las Vegas, which was previously known as the Artisan Hotel Boutique, is set to open on Friday, June 2.
The property is located near the Strip and vows to introduce "the idea of cannabis-friendly hospitality."
All 64 rooms on the property have been redesigned with finishes that minimize the impacts of marijuana smoke. Plus, there will be a designated floor with "420 friendly" rooms.
Room rates for this weekend are around $200.
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CNN contributed to this report.