According to the California Highway Patrol, the collision was reported about 12:20 a.m. just east of the 710 Freeway interchange. The deceased was not immediately identified.
A SigAlert was issued as crews worked to remove at least one of the damaged vehicles from blocking lanes.
The westbound side of the freeway was reopened shortly after 4:30 a.m., the CHP said.
The cause of the crash is under investigation.