Firefighters were dispatched shortly before 4:30 a.m. to the structure fire in the 5600 block of Atlantic Avenue.
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News video from the scene showed flames and smoke emanating from the roof of the building.
Paramedics rushed the injured firefighters to a hospital. No other injuries were reported.
The estimated damage caused by the incident was described as significant but a specific figure was not immediately available.
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The cause of the fire is under investigation.