The crash happened just before 10:30 p.m. near Santa Monica Boulevard, causing a full closure of the southbound side of the freeway, according to the California Highway Patrol.
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Authorities say the pedestrian, only identified as a 66-year-old man, had been seen running on the shoulder of the freeway.
It's unclear why he ran into lanes before being hit by what is believed to be a white Toyota sedan. That driver of that car did not stay at the scene.
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No further details were immediately known.