Just before 11 p.m., first responders appeared to have gotten the man safely down from the overpass. Lanes were then slowly reopening but traffic was still heavily backed up.
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A Sigalert was issued just before 7 p.m. on the 405 at Manchester Boulevard in Inglewood, the California Highway Patrol announced.
Two lanes later opened on both the northbound and southbound sides of the freeway.
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Drivers in the area were urged to drive with caution or seek an alternate route.