The school announced the lockdown shortly after 3 p.m, declaring a "campus emergency" and telling students and staff to shelter in place.
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A tweet said sheriff's deputies were searching for a suspect in a stabbing.
The Los Angeles County Sheriff's Department says a call for help was made around 2 p.m. and deputies on campus heard screams for help, then found a bleeding stabbing victim in a parking garage.
The suspect was last seen running away from the garage in the area of Heliotrope and Melrose. The victim was not a student.
Officials later said the victim had died.
The lockdown was lifted around 5:30 p.m.
A knife was recovered from the scene.
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Online classes were still being held Monday, the school said.