The fire broke out at the building in the 700 block of East 9th Street between San Pedro and Crocker streets.
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Video captured by AIR7HD showed flames rising from the roof, spreading smoke through the area nearby.
The fire spread through at least three commercial units. It took 117 LAFD firefighters more than an hour to extinguish the flames.
No injuries were reported.
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Firefighters remained at scene overnight to overhaul a large amount of smoldering debris. The cause of the fire remains under investigation.