The event featured music, dancing, guest speakers and the talents of many Native American artists and performers.
In 2017, the L.A. City Council approved a resolution establishing the second Monday in October as the holiday.
Councilmember Mitch O'Farrell, who is a member of the Wyandotte Nation, was a driving force behind the effort.
He spoke to the crowd at the event, recognizing the historic struggles faced by Native Americans.
Across the nation, there has been a growing movement to replace Columbus Day with Indigenous Peoples Day.
L.A. is one of several other cities nationwide opting to drop Columbus Day in favor of Indigenous Peoples Day.