Firefighters and deputies responded to the 4800 block of Olanda Street around 4:30 p.m., according to the Los Angeles County Sheriff's Department.
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The suspect was holed up in the home when firefighters arrived to extinguish the blaze and at some point, gunshots rang out.
Deputies took the suspect into custody when he was outside the home.
A sheriff's helicopter landed on the street as firefighters began to get a better handle of the blaze. The blaze was extinguished just after 5 p.m., but the home was damaged and flames may have spread to a nearby house.
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It's unclear if anyone else was inside the home or what caused the fire.
No injuries were reported.