The crash happened in an unincorporated area of the Santa Monica Mountains north of Malibu shortly after 8:30 p.m.
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One person, a woman in her 20s, died at the scene, four others suffered critical injuries, and two other crash victims received minor injuries, according to authorities
The four crash victims with critical injuries were flown to local hospitals, the Los Angeles County Fire Department said.
Malibu Canyon Road was closed for the investigation. CHP issued a SigAlert for Malibu Canyon just south of Piuma Road, and expects the closure to last for at least three hours.
Traffic lanes were closed in both directions. Drivers should seek alternate routes.
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No further details were immediately known.
This is a developing story. Please check back for updated information.