The crash occurred around 7:30 a.m. on Malibu Canyon Road between Pacific Coast Highway and Harbor Vista Drive.
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Both directions of Malibu Canyon Road just north of PCH was shut down. The duration of the closure was unknown.
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At least one person suffered a moderate head injury and was transported to the Ronald Reagan UCLA Medical Center, according to a California Highway Patrol log about the incident.
The cause of the wreck was not immediately known.