The fire started around 6:30 p.m. Sunday on E. 71st Street, according to the Los Angeles Fire Department.
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The body of a 52-year-old man was found inside the home after firefighters extinguished the flames that were contained to just one room within the home. It's unclear when and how the man died.
Fire officials say there were no working smoke detectors and the building did not have any fire sprinklers.
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The cause of the fire remains under investigation.