The crash was reported just before 3 a.m. Monday along the eastbound lanes of the San Bernardino (10) Freeway at Via Verde Street, according to the California Highway Patrol.
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The semi-truck was described as a tanker with about 80,000 pounds of gasoline but none of the fuel was leaking, according to a CHP log.
All lanes have since reopened.
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City News Service, Inc. contributed to this report.