The shipment included 3,810 pounds of methamphetamine, along with 56 pounds of cocaine and 11.5 pounds of heroin, federal authorities said.
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Officers with U.S. Customs and Border Protection seized three shipping containers containing the drugs on Jan. 11 at the Los Angeles/Long Beach seaport.
Feds seize 1.7 tons of drugs at Long Beach port
Following an investigation, federal authorities in Australia this week arrested two U.S. citizens and four Australian citizens.
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Federal officials say the seizure dealt a significant blow to the drug trafficking organization behind the shipments.
"Along with our law enforcement partners here and around the world, we continue in a day-to-day battle against the blight of methamphetamine that continues to devastate our communities," said Joseph Macias, Special Agent-In-Charge for Homeland Security Investigations Los Angeles. "Through a collaborative effort -- pooling our information, resources and expertise - we are keeping this dangerous contraband from reaching our streets and potentially saving lives."