The standoff started when officers responded to Western and Melrose avenues around 3:50 a.m., according to the Los Angeles Police Department.
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The bus driver had reportedly noticed a man in the back of the bus with a weapon, possibly a handgun. The driver got out and disabled the bus while waiting for police to arrive.
At least one SWAT vehicle also responded to the scene. In an attempt to get the man out, authorities sent a drone and the department's "robot dog" into the bus.
Standoff underway with possibly armed man on Metro bus in Hollywood
The man eventually made his way out of the bus and was taken into custody without incident.
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Surface streets in the area were shut down as a precaution.