The collision was reported around 3:20 p.m. near Coldwater Canyon Avenue and Raymer Street.
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The vehicle was severely mangled in the crash. Firefighters cut through the wreckage to extricate a person inside the car but quickly declared the individual deceased.
The train was Metrolink 113 with service to Ventura County. There were 53 people on board, with no injuries reported.
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The cause of the collision remains under investigation.