The collision was reported around 3:20 p.m. near Coldwater Canyon Avenue and Raymer Street.
The vehicle was severely mangled in the crash. Firefighters cut through the wreckage to extricate a person inside the car but quickly declared the individual deceased.
The train was Metrolink 113 with service to Ventura County. There were 53 people on board, with no injuries reported.
The cause of the collision remains under investigation.