Authorities said the multiple-car crash happened around 9:47 a.m. in the westbound lanes of Interstate 96 in Livingston County.
The identities of those killed were not released, and the 11 others who were hurt suffered non-life-threatening injuries.
The freeway was closed for more than 12 hours, according to WXYZ-TV. Police said slick roads and white-out conditions from snow were factors in the crashes.
ABC News contributed to this report.
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