Nearly 200 migrants, many traveling with children, decided to apply for protection at the nation's busiest border crossing after many fled violence in their home countries, organizers said.
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As of Monday night, eight of the migrants were allowed to enter the immigration checkpoint and begin applying for asylum.
The U.S. Customs and Border Patrol informed Mexico it could let in eight people from the group of 20 migrants who had taken up position outside the border access point in San Ysidro, California.
According to caravan organizer Viridiana Vidal from Pueblo Sin Fronteras, agents rushed the migrants camping outside, saying, "We are ready now."
Mothers and children were let in first, according to Vidal. Three mothers, four kids and one 18-year-old man, traveling alone, were let in, Vidal said.
Dozens more migrants were waiting to be processed at the facility, which had said earlier Sunday, when they arrived, that the facility was too full to begin taking those seeking asylum in the U.S.
Also Monday, the U.S. Department of Justice said border agents had arrested 11 other members of the caravan who had allegedly tried to enter the United States illegally in areas separate from the official border crossing.
The DOJ has filed criminal charges against those 11.
The Border Patrol said it arrested the individuals in sections of the border that are 2-4 miles west of the official San Ysidro port of entry. One person in the group had previously been deported, according to DOJ.
"These eleven defendants face charges now because they believed themselves to be above the law," said U.S. Attorney Adam L. Braverman. "Those seeking entry into the United States must pledge fidelity to the law, not break them, or else face criminal prosecution."
Many of the migrants in the caravan had traveled through Central America and were from war-torn Honduras.
Wendi Yaneri Garcia says she's confident she will be released while her asylum case winds its way through the courts because she's traveling alone with her 2-year-old son, who has been sick.
"All I want is a place where I can work and raise my son," the 36-year-old said.
She said police in her hometown of Atlantida, Honduras, jailed her for protesting construction of a hydroelectric plant and that she received death threats after being released.
President Donald Trump and members of his Cabinet have been tracking the caravan of migrants, calling it a threat to the U.S. since it started March 25 in the Mexican city of Tapachula, near the Guatemala border.
Attorney General Jeff Sessions has called the caravan "a deliberate attempt to undermine our laws and overwhelm our system," pledging to send more immigration judges to the border to resolve cases if necessary.
Trump administration officials have railed against what they call America's "catch and release" policies that allow people requesting asylum to be released from custody into the U.S. while their claims make their way through the courts, a process that can last a year.
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The caravan's arrival at San Diego's San Ysidro border crossing marked the end of a monthlong journey by foot, freight train and bus for the migrants, many of whom said they feared for their lives in their home countries.
Nefi Hernandez, 24, said a gang in his hometown of San Pedro Sula, Honduras, threatened to kill him and his family if he did not sell drugs. He intended to seek asylum with his wife and baby daughter, who was born on the journey through Mexico.
Jose Cazares, 31, said he faced death threats in the Honduran city of Yoro because a gang member suspected of killing the mother of his children learned one of his sons reported the crime to police.
But the travelers faced an uncertain future as they asked for asylum. U.S. immigration lawyers warned them that they face possible separation from their children and detention for many months.
Homeland Security Secretary Kirstjen Nielsen said asylum claims will be resolved "efficiently and expeditiously." But she warned that any asylum seekers making false claims could be prosecuted, as could anyone who assists the migrants in doing so.
Administration officials and their allies claim that asylum fraud is growing and that many who seek it are coached on how to do so.
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If border inspectors say they don't have staff and space to accommodate nearly 200 people at once, organizers will put women with children and children traveling alone at the front of the line, said Bliss Requa-Trautz of the National Day Laborer Organizing Network. The rest will stay in Mexico and try another day.
The San Ysidro crossing can hold about 300 people temporarily, Pete Flores, U.S. Customs and Border Protection's San Diego field office director, said earlier this month.
Asylum seekers are typically held for up to three days at the border and then turned over to U.S. Immigration and Customs Enforcement. If they pass an asylum officer's initial screening, they may be detained or released into the U.S. with ankle monitors.
Maria de Los Angeles, 17, said she felt confident after speaking with an attorney that U.S. authorities would release her while her case wends its way through the courts because she was traveling alone with her 1-year-old son. She hoped to move in with a sister in San Francisco.
"I'm fired up to go because I believe in God and I believe everything will work out," she said.
She said she fled her home in Jutiapa, Honduras, because the father of her son threatened to kill her and their child.
ABC News contributed to this report.