Authorities said the crash happened around 5:30 p.m. in 1100 block of Pacific Coast Highway. It was a crash between a vehicle and motorcyclist, authorities said.
The motorcycle rider was taken to a nearby hospital in serious condition.
Multiple witnesses at the scene were being interviewed.
Authorities said the Pacific Coast Highway was closed for some time at the famous incline. It was reopened before 10 p.m.
The cause of the crash is under investigation.